{"id":131,"date":"2017-04-30T15:06:52","date_gmt":"2017-04-30T12:06:52","guid":{"rendered":"http:\/\/mde.biologia.gr\/evasom\/?p=131"},"modified":"2017-05-06T23:42:54","modified_gmt":"2017-05-06T20:42:54","slug":"%ce%b4%ce%bf%ce%bc%ce%b9%ce%ba%ce%ae-%ce%b2%ce%b9%ce%bf%ce%bb%ce%bf%ce%b3%ce%af%ce%b1-%cf%84%ce%bf%cf%85-%cf%80%ce%b1%cf%81%ce%ac%ce%b3%ce%bf%ce%bd%cf%84%ce%b1-%ce%bd%ce%ad%ce%ba%cf%81%cf%89%cf%83","status":"publish","type":"post","link":"https:\/\/mde.biologia.gr\/evasom\/2017\/04\/30\/%ce%b4%ce%bf%ce%bc%ce%b9%ce%ba%ce%ae-%ce%b2%ce%b9%ce%bf%ce%bb%ce%bf%ce%b3%ce%af%ce%b1-%cf%84%ce%bf%cf%85-%cf%80%ce%b1%cf%81%ce%ac%ce%b3%ce%bf%ce%bd%cf%84%ce%b1-%ce%bd%ce%ad%ce%ba%cf%81%cf%89%cf%83\/","title":{"rendered":"\u0397 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b4\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03bd\u03ad\u03ba\u03c1\u03c9\u03c3\u03b7\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd (TNF)"},"content":{"rendered":"

\u0397 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03b1\u03c5\u03c4\u03ae \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03c4\u03c1\u03b9\u03c3\u03b4\u03b9\u03ac\u03c3\u03c4\u03b1\u03c4\u03b7 (3D) \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c3\u03bf\u03bc\u03bf\u03af\u03c9\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c0\u03c4\u03c5\u03c7\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03c6\u03bf\u03b9\u03c4\u03b7\u03c4\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b5\u03c2 \u03c4\u03c9\u03bd \u03ba\u03bb\u03ac\u03b4\u03c9\u03bd \u03c5\u03b3\u03b5\u03af\u03b1\u03c2, \u03b5\u03c3\u03c4\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2. \u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1, \u03b7 \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03bc\u03bf\u03bd\u03c4\u03b5\u03bb\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03bd\u03ad\u03ba\u03c1\u03c9\u03c3\u03b7\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5 (TNF) \u03ac\u03b3\u03c1\u03b9\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03cd\u03c0\u03bf\u03c5. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u00a0\u03b5\u03bd \u03c3\u03c5\u03bd\u03c4\u03bf\u03bc\u03af\u03b1 \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03bf\u03b3\u03ba\u03bf\u03bd\u03b5\u03ba\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 1 (TNF-R1) . \u039f\u03b9 TNF \u03ba\u03b1\u03b9 TNF-R1 \u03c0\u03b1\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b7\u03c2 \u03bf\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2. \u039a\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5 TNFR-1, \u03b7 TNF \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 k\u0392 (\u039dF-kB), \u03ba\u03b1\u03c4\u03b1\u03bb\u03ae\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03c3\u03b5 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03ae \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf. \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03c9\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03ce\u03bd TNF \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03b8\u03b5\u03af \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03c9\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03b9\u03ce\u03bd \u03b5\u03bd\u03cc\u03c2 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03cc\u03c3\u03b9\u03bc\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03ba\u03bc\u03ac\u03b8\u03b7\u03c3\u03b7\u03c2.<\/p>\n

\u03a3\u03ba\u03bf\u03c0\u03cc\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7\u00a0\u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03c3\u03c5\u03bd\u03cc\u03bb\u03bf\u03c5 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03bc\u03ac\u03b8\u03b7\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03bd\u03b1 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03b8\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c0\u03c1\u03bf\u03c0\u03c4\u03c5\u03c7\u03b9\u03b1\u03ba\u03cc \u03bc\u03ac\u03b8\u03b7\u03bc\u03b1 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1\u03c2 \/ \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2.<\/span>\u00a0\u039f\u03b9 \u03bc<\/span>\u03b1\u03b8\u03b7\u03c3\u03b9\u03b1\u03ba\u03bf\u03af \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 \u03c4\u03c9\u03bd \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u03b4\u03b9\u03b4\u03b1\u03c3\u03ba\u03b1\u03bb\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 : (i)\u03b7 \u03b5\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03bc\u03b9\u03ba\u03ce\u03bd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03c9\u03bd \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03bc\u03ce\u03bd. (ii) \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2. (Iii) \u03b7 \u03b5\u03be\u03bf\u03b9\u03ba\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c0\u03bf\u03c5\u03b4\u03b1\u03c3\u03c4\u03ce\u03bd \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03bb\u03bf\u03b3\u03b9\u03c3\u03bc\u03b9\u03ba\u03cc \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c4\u03bf\u03bc\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 (Iv) \u03b5\u03be\u03bf\u03b9\u03ba\u03b5\u03af\u03c9\u03c3\u03b7\u00a0<\/span>\u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03bf\u03bc\u03b9\u03ba\u03ce\u03bd \u03b9\u03b4\u03b9\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u03c4\u03c9\u03bd \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd.<\/span><\/p>\n

\u0397 \u039c\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03bf\u03bc\u03bf\u03af\u03c9\u03c3\u03b7 \u00a0\u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 Accelrys-Discovery Studio Visualizer (DSV) \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b5\u03c2 \u03bc\u03bf\u03bd\u03c4\u03b5\u03bb\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03bd\u03ad\u03bc\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c4\u03c1\u03b5\u03b9\u03c2 \u0391\u03bd\u03b1\u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b2\u03b1\u03c3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03bf\u03bc\u03ad\u03c2: TNF-\u03b1 \u03b1\u03b3\u03c1\u03af\u03bf\u03c5 \u03c4\u03cd\u03c0\u03bf\u03c5 (wtTNF-a, PDB ID: 1TNF) \u03ba\u03b1\u03b9 \u00a0\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 TNF-a (M3S) (PDB ID: 5TSW). \u0397 \u0391\u03bd\u03ac\u03b8\u03b5\u03c3\u03b7 1 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae \u03b4\u03bf\u03bc\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c4\u03bf\u03c5 wtTNF-a, \u03ba\u03b1\u03b9 \u03b7 \u0391\u03bd\u03ac\u03b8\u03b5\u03c3\u03b7 2 \u03b5\u03c0\u03b9\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf TNF-a. \u039f\u03b9 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 wt \u03ba\u03b1\u03b9 mutual TNF-a \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b1 \u03c3\u03c4\u03b7\u03bd \u0391\u03bd\u03ac\u03b8\u03b5\u03c3\u03b7 2. \u0397 \u0391\u03bd\u03ac\u03b8\u03b5\u03c3\u03b7 3 \u03b1\u03c3\u03c7\u03bf\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c0\u03b5\u03b4\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03bc\u03bf\u03bd\u03ac\u03b4\u03c9\u03bd \u03b4\u03b9\u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03b1\u03c4\u03b1\u03bb\u03bf\u03af\u03c0\u03c9\u03bd \u03c4\u03bf\u03c5 TNF-R1.<\/p>\n

\u0388\u03bd\u03b1 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c7\u03ad\u03b4\u03b9\u03bf \u03b4\u03b9\u03b4\u03b1\u03c3\u03ba\u03b1\u03bb\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 4 \u03a3\u03c5\u03bd\u03b5\u03b4\u03c1\u03af\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 :<\/p>\n

\u03a3\u03c5\u03bd\u03b5\u03b4\u03c1\u03af\u03b1 1:\u00a0<\/span>\u0392\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b4\u03bf\u03bc\u03ae\u03c2, \u03c3\u03c5\u03bd\u03ac\u03c6\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 TNF \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b4\u03b9\u03b1\u03c1\u03b8\u03c1\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03ba\u03c4\u03b9\u03bc\u03ae\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 TNF \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 TNF-R \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u039f\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/span><\/p>\n

\u03a3\u03c5\u03bd\u03b5\u03b4\u03c1\u03af\u03b1 2: \u0395\u03c0\u03af\u03b4\u03b5\u03b9\u03be\u03b7 \u03bb\u03bf\u03b3\u03b9\u03c3\u03bc\u03b9\u03ba\u03bf\u03cd DSV \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b8\u03c5\u03c1\u03bf \u03bc\u03bf\u03bd\u03c4\u03b5\u03bb\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03bd\u03bf\u03cd \u03b2\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2 \u03b1\u03c0\u03cc \u03b5\u03ba\u03c0\u03b1\u03b9\u03b4\u03b5\u03c5\u03c4\u03ae (\u03c0\u03c1\u03ce\u03c4\u03b1 20 \u03bb\u03b5\u03c0\u03c4\u03ac \u03c3\u03c4\u03b7 \u03c4\u03ac\u03be\u03b7). \u039f\u03b9 \u03bc\u03b1\u03b8\u03b7\u03c4\u03ad\u03c2 \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b5\u03ba\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b5\u03c2 \u03bc\u03bf\u03bd\u03c4\u03b5\u03bb\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2. \u0395\u03bd\u03b1\u03c1\u03be\u03b7 \u0391\u03bd\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 1.<\/span><\/p>\n

\u03a3\u03c5\u03bd\u03b5\u03b4\u03c1\u03af\u03b1 3: \u039f\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u0391\u03bd\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 1 \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u0391\u03bd\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 2.<\/span><\/p>\n

\u03a3\u03c5\u03bd\u03b5\u03b4\u03c1\u03af\u03b1 4: \u039f\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u03b1\u03bd\u03b1\u03b8\u03ad\u03c3\u03b5\u03c9\u03bd\u00a0<\/span>\u00a02 \u03ba\u03b1\u03b9 3. \u0388\u03bd\u03b1\u03c1\u03be\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bc\u03b5 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u03b1\u03c0\u03cc \u03ba\u03ac\u03b8\u03b5 \u03c6\u03bf\u03b9\u03c4\u03b7\u03c4\u03ae, \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b2\u03c1\u03b1\u03c7\u03c5\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1\u03c2, \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ac \u03c0\u03bf\u03c5 \u03ad\u03bc\u03b1\u03b8\u03b1\u03bd. \u0397 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u03b8\u03b1 \u03ad\u03c7\u03b5\u03b9 \u00a0\u03bc\u03bf\u03c1\u03c6\u03ae \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ac \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ac. \u03a0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03bf\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03ba\u03bc\u03ac\u03b8\u03b7\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03c3\u03b5\u03bc\u03b9\u03bd\u03b1\u03c1\u03af\u03c9\u03bd \u03ae project \u03b1\u03c0\u03cc \u03bc\u03b1\u03b8\u03b7\u03c4\u03ad\u03c2, \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03ad\u03bb\u03b5\u03be\u03b1\u03bd \u03c3\u03c4\u03b9\u03c2 \u03b5\u03ba\u03c0\u03b1\u03b9\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b5\u03b4\u03c1\u03af\u03b5\u03c2.<\/span><\/p>\n

\u03a4\u03b1 \u03b1\u03bd\u03b1\u03bc\u03b5\u03bd\u03cc\u03bc\u03b5\u03bd\u03b1 \u03bc\u03b1\u03b8\u03b7\u03c3\u03b9\u03b1\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u03b5\u03ba\u03bc\u03ac\u03b8\u03b7\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9: <\/span><\/p>\n

1. \u0397 \u03b4\u03b9\u03b5\u03cd\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae\u03c2 \u03b9\u03b4\u03ad\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c4\u03bf\u03bc\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd. <\/span><\/p>\n

2. H \u03b1\u03c0\u03cc\u03ba\u03c4\u03b7\u03c3\u03b7 \u03b3\u03bd\u03ce\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b4\u03bf\u03bc\u03ad\u03c2 3D \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2. <\/span><\/p>\n

3. H \u03b1\u03c0\u03cc\u03ba\u03c4\u03b7\u03c3\u03b7 \u03b5\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c8\u03b7\u03c6\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ae \u03c3\u03b5\u03b9\u03c1\u03ac \u03bc\u03b1\u03b8\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd <\/span><\/p>\n

4. H \u03b3\u03bd\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b2\u03ac\u03c3\u03b7\u03c2 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03c4\u03cd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u00a0\u03bb\u03bf\u03b3\u03b9\u03c3\u03bc\u03b9\u03ba\u03bf\u03cd \u03b3\u03b9\u03b1 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03bf\u03bd\u03c4\u03b5\u03bb\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7, \u03ba\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03ad\u03c3\u03b7 \u03bd\u03b1 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03bf\u03c5\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03bc\u03bf\u03bd\u03c4\u03b5\u03bb\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ce\u03bd \u03b4\u03bf\u03bc\u03ce\u03bd pdb.<\/span><\/p>\n

\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd 4 \u03b4\u03c5\u03bd\u03b1\u03c4\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b1\u03b8\u03b7\u03c3\u03b9\u03b1\u03ba\u03ce\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd:<\/span><\/p>\n

    \n
  1. \u03a6\u03bf\u03b9\u03c4\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u0391\u03bd\u03b1\u03b8\u03ad\u03c3\u03b7\u03c2 1-3 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03bf\u03bc\u03ae PDB.<\/li>\n
  2. \u00a0\u0393\u03bd\u03ce\u03c3\u03b7 \u03c0\u03c1\u03b9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03b2\u03b1\u03c3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03b5\u03c1\u03c9\u03c4\u03b7\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ae\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae\u03c2<\/li>\n
  3. \u039c\u03b5\u03c4\u03b5\u03ba\u03c0\u03b1\u03b9\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1<\/li>\n
  4. \u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7<\/li>\n<\/ol>\n

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